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ea0081rc1.2 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Glucose alterations, insulin resistance, hypertension, and activation of the renin-aldosterone system are strictly associated in pediatric obesity

Antoniotti Valentina , Amore Martina , Bellone Simonetta , Ricotti Roberta , De Grandi Roberta , Caputo Marina , Spadaccini Daniele , Mancioppi Valentina , Aimaretti Gianluca , Prodam Flavia

Background: The increase of global childhood obesity has led to an increase of associated co-morbidities also at a young age. The pro-inflammatory state and insulin resistance are two master regulators of several complications, including hypertension and pre-diabetes frequently connected in a complex cross-talk.Aim: To evaluate the relationship between glucose alterations and blood pressure and the pathogenetic involvement of the renin-aldosterone system...

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ea0081p602 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mediterranean Diet and 12 months weight loss result in complex serum metabolomic and fecal metaproteomic changes in paediatric obesity

Spadaccini Daniele , Vita Vanella Virginia , Barberis Elettra , Ricotti Roberta , Bellone Simonetta , Bona Elisa , Antoniotti Valentina , Caputo Marina , Mancioppi Valentina , Rabbone Ivana , Manfredi Marcello , Prodam Flavia

Background: The relationship between composition and function of microbiota, obesity and nutrition has been increasingly studied and is still a challenge.Aims: To test whether in a group of 12 pediatric patients with obesity the treatment with a structured hospital and in-home Mediterranean Diet intervention had an impact on gut microbiota composition, function, and metabolite production, including Short chain fatty acids (SCFAs).M...

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Endocrine Abstracts

Glucose alterations, insulin resistance, hypertension, and activation of the renin-aldosterone system are strictly associated in pediatric obesity

Mediterranean Diet and 12 months weight loss result in complex serum metabolomic and fecal metaproteomic changes in paediatric obesity

BiosciAbstracts